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When plants are growing in unchallenging conditions, in which GSH-oxidizing compounds are kept relatively low by cellular antioxidant systems, the glutathione redox potential in subcellular compartments such as the cytosol, chloroplast, and mitochondria is maintained at highly reducing values

In pancreatic cancer cells, oncogenic K-Ras maintains the nucleotide pool via the MAPK-dependent signaling pathway, leading to MYC upregulation, and the use of MEK inhibitors reduces the incorporation of glutamine-derived nitrogen into purine nucleotides 38

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